Jonas Salk married Donna Lindsay, a social worker. They had three children together: Peter, Darrell, and Jonathan.

Jonas and Donna divorced after nearly three decades of marriage.

Salk married Françoise Gilot, a painter and writer who was previously in a long-term relationship with Pablo Picasso. This marriage brought him into the world of art and intellectual circles.

By all accounts, Salk was a devoted and supportive father, and the family life was a happy one.

Jonas Salk was survived by his wife, Françoise Gilot, his three sons, and several grandchildren.