Julia Louis-Dreyfus has been a vocal supporter of Democratic candidates and causes. She has actively campaigned and fundraised for various political campaigns throughout her career, often expressing her views on social media and in public appearances.

She has been a long time advocate for environmental issues.

Following her breast cancer diagnosis and recovery, Julia has become a vocal advocate for healthcare reform and access to affordable and quality healthcare for all. She has spoken out about the importance of early detection, preventative care, and the need for policies that support cancer research and treatment.