Holmes receives critical acclaim for her role in the independent film 'Pieces of April', portraying a young woman struggling to prepare Thanksgiving dinner for her dysfunctional family. Her performance earned her a Satellite Award nomination.

Holmes stars as Rachel Dawes in Christopher Nolan's 'Batman Begins', a major blockbuster that introduces her to a wider audience. Despite the film's success, she opts not to return for the sequel.

Holmes appears in 'Thank You for Smoking', a satirical comedy about a tobacco lobbyist. This role demonstrates her versatility in handling comedic material.

Holmes stars as Jackie Kennedy in the miniseries 'The Kennedys'. The role earns her praise and a Screen Actors Guild Award nomination.

Holmes appears in 'Woman in Gold' alongside Helen Mirren and Ryan Reynolds. The film tells the story of Maria Altmann's fight to reclaim Gustav Klimt paintings stolen from her family by the Nazis.