Leonardo da Vinci's remains were interred in the Collegiate Church of Saint Florentin at the Château d'Amboise. This event marked the end of Leonardo's extraordinary life and the beginning of his legacy as one of the most important figures in history. However, the exact location of his remains is unclear, because a collegiate church was destroyed in 1802.

Tax records indicate that by at least 1457 Leonardo lived in the household of his paternal grandfather, Antonio da Vinci. This move signifies a possible shift in Leonardo's upbringing and family dynamics, possibly indicating increased involvement from his father's side of the family.