Disney's Lilo & Stitch is an American science fiction media franchise that began in 2002 with the animated film of the same name written and directed by Chris Sanders and Dean DeBlois. The franchise, which consists of four animated films, three animated television series, a live-action adaptation, and several other spin-offs, is noted for its unusual and eclectic cast of fictional characters, both human and alien.

Stitch (Experiment 626) is one of the two title characters of the Lilo & Stitch franchise. Originally an illegal genetic experiment created by mad alien scientist Dr. Jumba Jookiba to cause chaos across the galaxy, he is marked by his short temper and mischievous behavior (traits that endear him to his friend Lilo, who adopted him as her "dog"). He is voiced by his creator and the film's co-writer and co-director, Chris Sanders, in all official media, except the Stitch! anime and Stitch & Ai, where he is voiced by Ben Diskin.

Lilo Pelekai (/ˈliːloʊ/ LEE-loh) (literally, "lost" in Hawaiian) is one of the two title characters of the franchise. She is a young Native Hawaiian girl who lives on the island of Kauaʻi with her older sister Nani and her extended family of alien visitors marooned on Earth. She is voiced by Daveigh Chase in all the films and Lilo & Stitch: The Series, except Lilo & Stitch 2: Stitch Has a Glitch where she was voiced by Dakota Fanning due to scheduling conflicts on Chase's part. In the 2025 live-action film, Lilo is portrayed by newcomer Maia Kealoha.

Lilo is a young girl with long, straight black hair and brown eyes. She is most often seen wearing a muʻumuʻu and sandals, but also wears other warm-weather clothing as well as traditional hula costumes. In Lilo & Stitch 2: Stitch Has a Glitch; her reflection in a mirror is compared to a picture of her young mother, suggesting that they look similar. In the episode "Skip" where an experiment (Experiment 089) is used to skip time ten then another ten years, it is mentioned that older Lilo looks a lot like her sister Nani.

Her spirited and highly eccentric personality, especially in light of her parents' death, has alienated her from her fellow children, yet Lilo makes the perfect best friend for Stitch, an alien experiment whom she adopts as her dog. Lilo attends hula school and her hobbies include the photography of tourists (especially obese people), talking about creatures from horror/sci-fi movies, and rehabilitating Jumba's experiments. In "Swapper", she meets Victoria, who turns out to have similar personalities to her and she becomes Lilo's only human friend.

Lilo is also known for being a passionate fan of Elvis Presley; this trait of hers is based on Lilo & Stitch director/writer Chris Sanders being a fan of Presley himself.

Lilo's parents died in a car accident some time before Lilo & Stitch (it is suggested that rain made road conditions treacherous), and they have not appeared in the series apart from three photographs: one of Lilo, Nani, and their parents having a picnic on the beach, a photograph of Lilo's mother winning the Hula contest at her school's May Day celebration, and a photo of Nani with her parents when she graduated to intermediate Hula.

Lilo's mother is depicted as kind and loving (and perhaps eccentric like her younger daughter), as well as an excellent hula dancer. She would placate her children by holding a family night, singing lullabies, and making up funny constellations. Lilo's father played the ukulele and was the one who coined the phrase ʻOhana means family, and family means nobody gets left behind or forgotten. Lilo loves and misses her parents very much; she keeps a picture of them under her pillow and initially would not allow Stitch to touch it.