Doctors is a British medical soap opera which began broadcasting on BBC One on 26 March 2000. Set in the fictional West Midlands town of Letherbridge, the soap follows the lives of the staff and patients of the Mill Health Centre, a fictional NHS doctor's surgery, as well as its two sister surgeries, the University of Letherbridge Campus Surgery and Sutton Vale Surgery. The following is a list of characters that first appeared in Doctors in 2022, by order of first appearance. All characters are introduced by the programme's executive producer, Mike Hobson. Hazeem Durrani (Ashraf Ejhbair) began appearing in January after he was introduced as a relative of Ruhma Carter's (Bharti Patel). Clare Wille then joined the cast in February as Davina Hargrove, a friend of Zara Carmichael's (Elisabeth Dermot Walsh), as well as Rosie Colton (Janice Connolly) being introduced as a receptionist at Sutton Vale. Princess Buchanan (Laura White) made her first appearance in March as a trainee doctor from Sutton Vale, as well as nurse practitioner Maeve Ludlow (Clelia Murphy). Kia Pegg then debuted in April as receptionist Scarlett Kiernan. Roxy Piper (Fiona Skinner) then joined in September as Emma Reid's (Dido Miles) neighbour. Then in October, Samuel Morgan-Davies joined the cast as police constable Gareth Lewis. Additionally, multiple other characters appear throughout the year.

Hazeem Durrani, portrayed by Ashraf Ejjbair, first appeared on 17 January 2022 and made his final appearance on 5 April 2022. Ejjbair announced via Instagram that he would be appearing in Doctors on a recurring basis and that he began filming for the soap in September 2021. Hazeem was introduced to the series as a relative of Ruhma Carter (Bharti Patel) who stays with her following travelling in Thailand. He is followed by Daisha Rashid (Sophie Kandola), with whom he shared a casual relationship with whilst travelling. Daisha tells Hazeem and Ruhma that she has nowhere to stay due to her relationship with her parents being tumultuous and informs them that she is set to stay in a hostel. Ruhma allows her to stay at hers alongside Hazeem, to his annoyance since he does not want a serious relationship. He eventually dumps her and after realising that Ruhma and Daisha have formed a close bond, he demands they cut contact with each other.

Ruhma introduces Hazeem to Bear Sylvester (Dex Lee), who sets Hazeem up with various job interviews. However, he turns down potential jobs and misses an interview due to falling asleep, leading Ruhma to demand he gets a job and pays rent for living with her. She tells him to "get his act together" and gets him a temporary job on reception at the Mill Health Centre. What to Watch's Simon Timblick described Hazeem as "lazy". Receptionists Karen Hollins (Jan Pearson) and Valerie Pitman (Sarah Moyle) show different attitudes towards having Hazeem work with them on reception. Karen is unhappy with his lack of work experience, while Valerie believes having him work at the Mill will be a good experience and trains him. However, Hazeem "is left shaken" after his first patient encounter. However, he eventually "finds his groove". After receiving an offer for a better job, Hazeem makes the decision to leave the Mill.

Davinia Hargrove, portrayed by Clare Wille, appeared between 8 and 22 February 2022. She was introduced as an old school friend of Zara Carmichael (Elisabeth Dermot Walsh) after she moves to the Midlands to pursue growth in her clothing company. Timblick (What to Watch) described Davinia as a "high flying fashion businesswoman". It was confirmed by Timblick that her arrival in the fictional town would mean that she will share a lot of scenes with Zara. He also hinted that the rekindling of their friendship could mean the end of Zara's friendship with long-term friend Emma Reid (Dido Miles). Zara is "thrilled" to have Davinia in town and she invites Zara to a fashion show where she admits that she does not have many friends.

Afterwards, Davinia asks Zara if she can act as a cover story by telling her husband, Julian Hargrove (Henry Douthwaite), that she is staying there. She explains that she is cheating on Julian and needs a cover for her secret relationship. Due to loving Davinia's "go-getter attitude", she agrees, which earns the disapproval of Zara's partner, Daniel Granger (Matthew Chambers). Julian unexpectedly travels from London and turns up at Zara's house to find that Davinia is not there, and after she takes several hours to show up, he questions why she is lying to him. The two argue and he agrees to go back to London. Davinia and Zara meet up with fellow former classmate Belinda Cooper (Emma Cooke), who admits that she was nervous of the pair whilst at school. Davinia takes pride in her mean reputation, nastily reminding Belinda about an incident where a school teacher made her cry, leaving Zara to be "taken aback by her bitchy behaviour". Zara realises that Davinia has not grown up and decides to cut their friendship off.

Rosie Colton, portrayed by Janice Connolly, first appeared on 24 February 2022. She was introduced as a receptionist at Sutton Vale Surgery, which the Mill take over. When she meets business manager Bear Sylvester (Dex Lee) and surgery partners Zara Carmichael (Elisabeth Dermot Walsh) and Daniel Granger (Matthew Chambers), Rosie fills them in on the details of Sutton Vale. This includes the case of missing person Dr. Jacob Ashdown, who randomly went missing. Rosie gets emotional on several occasions over his disappearance. Rosie is shown to be hapless with technology and co-worker Princess Buchanan (Laura White) makes a comment that she is ready to retire, which new lead GP of Sutton Vale, Al Haskey (Ian Midlane), is disappointed about. Rosie warns Al that Princess is trouble and that there is something about her that he should watch out for.

Jimmi Clay (Adrian Lewis Morgan) takes over as lead GP at Sutton Vale due to Al prioritising the care of his mother, which Rosie struggles with. He "has concerns" about Rosie's inability to cope with changes at her surgery, such as being unable to operate the new computer system and the staff changes. He speaks to Rosie about her situation and unknowingly persuades Rosie to retire. He asks Rosie to arrange a staff meeting which she gets upset at; Maeve Ludlow (Clelia Murphy) informs Jimmi that it is Rosie's last day at Sutton Vale and hints that she may feel unappreciated. He then arranges a last-minute goodbye party for her. Months after her departure, she learns that Jacob has been found dead and arrives at the crime scene with flowers. She informs DI Mick Hartley (Martin Walsh) that she believes Princess murdered Jacob.

Rosie initially left in an episode broadcast on 6 September 2022. In March 2023, Connolly announced via Twitter that she would be returning to Doctors as Rosie later in the year. The character made an unexpected return in May 2023, with her hiring at the Mill kept a secret from everyone, since Bear decided to keep it private. Surgery partner Nina Bulsara (Wendi Peters) worries that her hiring is a mistake. However, she proves herself to be capable and is later promoted to deputy business manager. Months later, Rosie takes another job after Zara speaks to her horribly.