Madonna's mother, Madonna Louise (née Fortin), died of breast cancer when Madonna was five years old. This event had a significant impact on Madonna's early life and family dynamics.

Madonna Louise Ciccone was born in Bay City, Michigan, to Roman Catholic parents Madonna Louise (née Fortin) and Silvio Anthony 'Tony' Ciccone. This marks the beginning of her life and future career as a renowned singer, songwriter, and actress.