Margaret Crane began working at Organon Pharmaceuticals (a division of Akzo Nobel) in the late 1960s. Her initial role was in graphic design and product promotion.

While working at Organon, Crane observed that laboratory technicians used test tubes in the lab to conduct pregnancy tests. She had the insight to miniaturize and simplify the process for home use, leading to her conceptualization of the first home pregnancy test.

Crane, with the support of her then-boyfriend, a lawyer, filed for a patent for her home pregnancy test invention. She listed herself as the inventor, which was crucial given the historical context of women in STEM fields.

Margaret Crane's patent for the home pregnancy test was approved. This marked a significant achievement, validating her invention and its potential impact on women's healthcare.

Even after her patent was approved, Crane remained involved, in some capacity, with the development and marketing of the home pregnancy test, though details are limited. Her initial idea laid the groundwork for the product that eventually became a global phenomenon.