Weis wrote the "Star of the Guardians" series, a space opera series blending science fiction and fantasy elements. This series allowed her to explore different themes and genres beyond the typical high fantasy of Dragonlance.

Co-authored with Tracy Hickman, the "Death Gate Cycle" is a seven-book fantasy series that is critically acclaimed. It is characterized by its complex world-building, compelling characters, and thought-provoking themes.

Weis wrote the "Sovereign Stone" trilogy, a standalone fantasy series set in a unique world with its own distinct mythology and magic system. This series showcases her ability to create entirely new and engaging worlds.