Marjorie Joyner died of heart failure at her home in the Bronzeville neighborhood of Chicago, Illinois, at the age of 98. Her death marked the end of a life dedicated to entrepreneurship, innovation in the hair care industry, and activism.

Marjorie Joyner, along with Mary McLeod Bethune and U.S. congressman William Dawson, founded the sorority and fraternity Alpha Chi Pi Omega dedicated to the advancement and promotion of the beauty industry.