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The unit opened in June 1993. The unit serves as the University of Texas Medical Branch hub site for treatment of HIV and other infectious diseases.[2] As a result, the Stiles facility houses many HIV positive prisoners.[3] A hospice for prisoners with HIV opened at Stiles in 1997.[4]
The unit has offered Buddhist meditation classes since 2003.[5]
In 2011 the metal products plant closed; its operations were consolidated to the plants at the Coffield Unit and the Powledge Unit.[6]