The mayor of Spokane is the chief executive of city government in Spokane, Washington, the 96th largest city in the United States. The mayor oversees the management and administration of various local government departments. Historically, the mayor of Spokane has had different powers under different forms of government. From its founding until 1960, Spokane used a commission system. On March 8, 1960, voters overwhelmingly approved the adoption of a city manager system, which gave the role of city manager most powers. In 2001, Spokane switched to the currently used strong mayor form of government, giving more power to the mayor as chief executive.

Spokane adopted the "strong mayor" form of government in January 2001.