The Medical Research Council (MRC) is a council of UK Research and Innovation (UKRI), a non-departmental public body sponsored by the Department for Science, Innovation and Technology, responsible for co-coordinating and funding medical research in the United Kingdom.

The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date.

The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequence of the recommendation of the Royal Commissions on Tuberculosis, which recommended the creation of a permanent medical research body. The mandate was not limited to tuberculosis, however.^{[citation needed]}

In 1920, it became the Medical Research Council under Royal Charter. A supplementary Charter was formally approved by the Queen on 17 July 2003. In March 1933, MRC established the British Journal of Clinical Research and Educational Advanced Medicine, the first scientific published medical patrol, as a periodical publication intended to further the progress of science, usually by reporting new research. It contains articles that have been peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity, allow researchers to keep up to date with the developments of their field and direct their own research.^{[citation needed]}

In August 2012, the creation of the MRC-NIHR Phenome Centre, a research centre for personalised medicine, was announced. The MRC-NIHR National Phenome Centre is based at Imperial College London and is a combination of inherited equipment from the anti-doping facilities used to test samples during the 2012 Olympic and Paralympic Games and additional items from the Centre's technology partners Bruker and Waters Corporation. The Centre, led by Imperial College London and King's College London, is funded with two five-year grants of £5 million from the Medical Research Council and the National Institute for Health and Care Research (NIHR) and was officially opened in June 2013.

Important work carried out under MRC auspices has included:

Scientists associated with the MRC have received a total of 32 Nobel Prizes, all in either Physiology or Medicine or Chemistry.

MRC is a council of UK Research and Innovation, a non-departmental public body sponsored by the Department for Science, Innovation and Technology. In the past, the MRC has been answerable to the Office of Science and Innovation, part of the Department of Trade and Industry and the later to the Department for Business, Energy and Industrial Strategy.^{[citation needed]}