While precise details of her early career steps are difficult to determine, it's reasonable to assume that she initially gained experience in writing or creative fields before transitioning into video games. This could include writing articles, blog posts, or working on smaller narrative projects. Her work in interactive fiction may have predated her full-time video game work.

Meg Jayanth served as the main writer and designer on 80 Days, an interactive fiction game developed by Inkle. The game is a reimagining of Jules Verne's Around the World in Eighty Days and received critical acclaim for its innovative narrative design, branching storylines, and compelling characters. The project brought significant recognition to Jayanth, establishing her as a prominent talent in the industry.

She received a Nomination for a Writers' Guild of Great Britain Award for her work on 80 Days.

After the success of 80 Days, Jayanth continued to work as a freelance narrative designer and writer, lending her talents to various video game projects. While specific titles she's worked on might not all be publicly known, she has collaborated with diverse studios, contributing to the story, characters, and world-building of various games.

Meg Jayanth contributed to the writing of Sunless Skies. This is a gothic horror, space-exploration game.

Meg Jayanth continues to actively contribute to the video game industry, both through her direct involvement in projects and through her advocacy for better representation, inclusivity, and narrative quality in games. She remains a prominent voice in discussions surrounding storytelling and design in the interactive medium.