Chartoff played the role of Liza Walton on the soap opera Search for Tomorrow.

Throughout the 1980s and 1990s, Chartoff appeared in numerous television shows, often in guest roles or recurring capacities. Specific details of all her roles are not easily available, but this period solidified her presence in the television industry.

Chartoff is most famously known for voicing Didi Pickles on the popular animated children's television series Rugrats. This role provided her with significant recognition and solidified her legacy in voice acting.

Chartoff appeared in 'The Secret World of Alex Mack' as Barbara, in the episode 'The Accident'.

She reprised her role as Didi Pickles in the Rugrats spin-off series All Grown Up!, extending her involvement with the beloved characters. This allowed audiences to see an older version of Didi as the Rugrats grew into teenagers.

Chartoff reprised her iconic role as Didi Pickles in the 2021 reboot of Rugrats on Paramount+. This highlights the enduring popularity of the series and her enduring connection to the character.