Lynskey began her recurring role as Rose in the popular sitcom "Two and a Half Men". Rose was Charlie Harper's stalker and obsessed neighbor. She appeared in over 60 episodes throughout the show's run.

Lynskey starred as Michelle Pierson in the HBO series "Togetherness", which explored the complexities of marriage and relationships. Her performance received critical acclaim, highlighting her ability to portray nuanced and relatable characters.

Melanie appeared in "Castle Rock", a horror series based on the stories of Stephen King. She played Molly Strand. This role allowed her to showcase her versatility in a darker and more suspenseful genre.

Lynskey stars as Shauna Shipman in the critically acclaimed Showtime series "Yellowjackets", a drama about a high school soccer team that survives a plane crash in the wilderness. Her performance has earned her significant praise and accolades, including a Primetime Emmy Award.