Methadone intermediate

Methadone intermediate
Clinical data
Routes of; administration	N/A
ATC code	none;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class A1 (Narcotic drugs); DE: Anlage II (Authorized trade only, not prescriptible); UN: Narcotic Schedule I;
Identifiers
	IUPAC name 4-cyano-2-dimethylamino-4,4-diphenylbutane;
CAS Number	125-79-1;
PubChem CID	31331;
ChemSpider	29065;
UNII	0GYB2HJA89;
KEGG	C22686;
CompTox Dashboard (EPA)	DTXSID1048912 ;
ECHA InfoCard	100.004.324
Chemical and physical data
Formula	C19H22N2
Molar mass	278.399 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(CC(C#N)(C1=CC=CC=C1)C2=CC=CC=C2)N(C)C;
	InChI InChI=1S/C19H22N2/c1-16(21(2)3)14-19(15-20,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,16H,14H2,1-3H3; Key:GJJQIGFCGLPOQK-UHFFFAOYSA-N;

Methadone intermediate (pre-methadone, methadone nitrile, dimethylaminodiphenylbutanonitrile) is a methadone precursor scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9254. The 2014 annual manufacturing quota was 32 875 kilos.^[3] It is listed as a Schedule I drug in Canada,^[4] but is only significant as a precursor for methadone, as it does not have analgesic activity in its own right, though it does show some atropine-like activity.^[5]

References

^ "STANDARD FOR THE UNIFORM SCHEDULING OF MEDICINES AND POISONS". Federal Register of Legislation. October 2020. Archived from the original on 2021-01-25. Retrieved 2021-08-15.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ "Quotas - Conversion Factors for Controlled Substances". Archived from the original on 2016-03-02. Retrieved 2016-02-28.
^ "Controlled Drugs and Substances Act (S.C. 1996, c. 19)". Justice Laws Website. Government of Canada. 24 November 2023.
^ Janssen PA (1960). "VII Nitriles". Diphenylpropylamines. Synthetic Analgesics. Vol. 1. Pergamon Press. pp. 122–128. LCCN 59-13814.

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[1] "STANDARD FOR THE UNIFORM SCHEDULING OF MEDICINES AND POISONS". Federal Register of Legislation. October 2020. Archived from the original on 2021-01-25. Retrieved 2021-08-15.

[2] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[3] "Quotas - Conversion Factors for Controlled Substances". Archived from the original on 2016-03-02. Retrieved 2016-02-28.

[4] "Controlled Drugs and Substances Act (S.C. 1996, c. 19)". Justice Laws Website. Government of Canada. 24 November 2023.

[5] Janssen PA (1960). "VII Nitriles". Diphenylpropylamines. Synthetic Analgesics. Vol. 1. Pergamon Press. pp. 122–128. LCCN 59-13814.

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Clinical data

Routes of administration	N/A
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance)^[1] BR: Class A1 (Narcotic drugs)^[2] DE: Anlage II (Authorized trade only, not prescriptible) UN: Narcotic Schedule I
Identifiers
IUPAC name 4-cyano-2-dimethylamino-4,4-diphenylbutane
CAS Number	125-79-1
PubChem CID	31331
ChemSpider	29065
UNII	0GYB2HJA89
KEGG	C22686
CompTox Dashboard (EPA)	DTXSID1048912
ECHA InfoCard	100.004.324
Chemical and physical data
Formula	C₁₉H₂₂N₂
Molar mass	278.399 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(CC(C#N)(C1=CC=CC=C1)C2=CC=CC=C2)N(C)C
InChI InChI=1S/C19H22N2/c1-16(21(2)3)14-19(15-20,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,16H,14H2,1-3H3 Key:GJJQIGFCGLPOQK-UHFFFAOYSA-N