Goth began auditioning for films, marking her transition from modeling to acting.

Goth made her film debut in Lars von Trier's Nymphomaniac, playing a role alongside Willem Dafoe.

Goth appeared in the post-apocalyptic thriller The Survivalist and the disaster adventure-thriller Everest.

Goth starred in the horror film A Cure for Wellness, directed by Gore Verbinski.

Goth had supporting roles in Luca Guadagnino's remake of Suspiria and the sci-fi mystery film High Life.

Goth played the lead roles in Ti West's slasher films X, Pearl, and MaXXXine, establishing herself as a scream queen.