Miamisburg (/maɪˈæmizbɜːrɡ/ my-AM-eez-burg) is a city in southern Montgomery County, Ohio, United States. The population was 19,923 at the 2020 census. A suburb of Dayton, it is part of the Dayton metropolitan area. Named after the Miami people, Miamisburg is known for its industrial history, particularly its nuclear operations during World War II.

European-Americans started calling their first community "Hole's Station" circa 1797, when Zechariah Hole settled there with his family from Virginia and built a stockade on the west bank of the Miami River opposite the mouth of Bear Creek. The stockade attracted squatters, surveying parties, and other settlers who had taken grants to live in the local cabins until they could build their own; hence the little community became known as "Hole's Station". Settlers came west primarily from Pennsylvania. Miamisburg was incorporated in 1832 as a village; it achieved city status in the 1920s.

By 1827, the Miami and Erie Canal was under construction through the community, which improved transportation of people and goods through the region. The formal opening took place in January 1829, when the Governor Brown was the first packet boat to go through the settlement. Also that year the first boats from Cincinnati had arrived and passed through Miamisburg to get to Dayton. By 1834 the canal had been extended to Piqua, and many businesses along the river grew. The 1840s and the 1850s were brought the best of times to the canals.^{[citation needed]}

George Kinder, a local resident, shipped bags of food to Ireland during its Great Famine; these also contained his address, with ads saying that he was hiring immigrant workers. Some Irish immigrants did come to Miamisburg and surrounding cities in search of work.^{[citation needed]}

Miamisburg was the site of one of the first post-war U.S. Atomic Energy Commission (AEC) facilities, beginning in 1947. The Dayton area had supported numerous secret operations for the War Department during World War II. As the war ended, the majority of these operations were moved to the Miamisburg Mound Laboratory, which was operated by the Monsanto Chemical Company. The Mound Labs were to monitor all aspects of the US nuclear defense stockpile.^{[citation needed]}

The Mound Plant, built in 1947, was situated on a 306-acre (124 ha) site in the city 10 miles (16 km) south of Dayton. The workers, who numbered more than 2,000 at the height of the production, made plutonium detonators for nuclear weapons. Their work was very classified. The plant had a small army of security guards and was ringed by chain-link fencing and razor wire. When the Cold War ended, the plant discontinued the detonator work, but it continued to make nuclear power generators for space probes.^{[citation needed]}

In May 1993 U.S. Department of Energy decided to end all production at the Mound. This move affected 2,100 employees in the local area. By 1996 cleanup of radioactive and hazardous waste was the main activity at the Plant. The Mound Development Corporation spearheaded the creation of the Mound Advanced Technology Center in the redevelopment of the plant, with the Montgomery County Regional Dispatch Center joining 14 other tenants in March 2009. In December 2010, the Dayton Police Department became the 17th law enforcement agency, along with 11 fire departments, to be dispatched from the regional center.^{[citation needed]}

On September 10, 1978, 15 cars of a Conrail freight train derailed as the result of a hot box, caused by uneven distribution of steel ingots in a gondola loaded at Buffalo, New York by Republic Steel. They demolished a house at the Pearl Street crossing and killed three of its five occupants. As a result of a cooperative investigation by the Miamisburg Police Department and the National Transportation Safety Board, the deaths were ruled homicides by the Montgomery County Coroner.^{[citation needed]}