Mir-650 microRNA precursor family

mir-650
mir-650
Identifiers
Symbol	mir-650
Rfam	RF00952
miRBase family	MIPF0000457
Other data
RNA type	microRNA
Domain	Eukaryota;
PDB structures	PDBe

In molecular biology mir-650 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Diabetic and Non-Diabetic Heart Failure

miR-650 is one of a group of six miRNAs with altered expression levels in diabetic and non-diabetic heart failure. This altered expression corresponds to various enriched cardiac dysfunctions.^[1]

NDRG2 regulation

miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene.^[2] There is direct regulation of this gene at a transcriptional level, leading to repressed NDRG2 expression.

References

^ Greco S, Fasanaro P, Castelvecchio S, D'Alessandra Y, Arcelli D, Di Donato M, Malavazos A, Capogrossi MC, Menicanti L, Martelli F (June 2012). "MicroRNA dysregulation in diabetic ischemic heart failure patients". Diabetes. 61 (6): 1633–41. doi:10.2337/db11-0952. PMC 3357263. PMID 22427379.
^ Feng L, Xie Y, Zhang H, Wu Y (March 2011). "Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650". Biochemical and Biophysical Research Communications. 406 (4): 534–8. doi:10.1016/j.bbrc.2011.02.081. PMID 21352815.

Lario S, Ramírez-Lázaro MJ, Aransay AM, Lozano JJ, Montserrat A, Casalots Á, Junquera F, Álvarez J, Segura F, Campo R, Calvet X (August 2012). "microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population". Clinical Microbiology and Infection. 18 (8): E273-82. doi:10.1111/j.1469-0691.2012.03849.x. PMID 22524533.
Girardi C, De Pittà C, Casara S, Sales G, Lanfranchi G, Celotti L, Mognato M (2012). Battista JR (ed.). "Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity". PLOS ONE. 7 (2) e31293. Bibcode:2012PLoSO...731293G. doi:10.1371/journal.pone.0031293. PMC 3276573. PMID 22347458.
Abdalla MA, Haj-Ahmad Y (2012). "Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients". Journal of Cancer. 3: 19–31. doi:10.7150/jca.3.19. PMC 3245605. PMID 22211142.
Chan E, Patel R, Nallur S, Ratner E, Bacchiocchi A, Hoyt K, Szpakowski S, Godshalk S, Ariyan S, Sznol M, Halaban R, Krauthammer M, Tuck D, Slack FJ, Weidhaas JB (June 2011). "MicroRNA signatures differentiate melanoma subtypes". Cell Cycle. 10 (11): 1845–52. doi:10.4161/cc.10.11.15777. PMC 3233487. PMID 21543894.
Chien WW, Domenech C, Catallo R, Kaddar T, Magaud JP, Salles G, Ffrench M (April 2011). "Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway". Oncogene. 30 (16): 1880–91. doi:10.1038/onc.2010.570. PMID 21170085.
Zhang X, Zhu W, Zhang J, Huo S, Zhou L, Gu Z, Zhang M (April 2010). "MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity". Biochemical and Biophysical Research Communications. 395 (2): 275–80. doi:10.1016/j.bbrc.2010.04.005. PMID 20381459.
Das S (May 2009). "Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family". Molecular Biology and Evolution. 26 (5): 1179–89. doi:10.1093/molbev/msp035. PMC 2727374. PMID 19246621.

External links

Page for mir-650 microRNA precursor family at Rfam

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[pmid22427379-1] Greco S, Fasanaro P, Castelvecchio S, D'Alessandra Y, Arcelli D, Di Donato M, Malavazos A, Capogrossi MC, Menicanti L, Martelli F (June 2012). "MicroRNA dysregulation in diabetic ischemic heart failure patients". Diabetes. 61 (6): 1633–41. doi:10.2337/db11-0952. PMC 3357263. PMID 22427379.

[pmid21352815-2] Feng L, Xie Y, Zhang H, Wu Y (March 2011). "Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650". Biochemical and Biophysical Research Communications. 406 (4): 534–8. doi:10.1016/j.bbrc.2011.02.081. PMID 21352815.

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[2]

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