| mir-652 | |
|---|---|
| Identifiers | |
| Symbol | mir-652 |
| Rfam | RF00872 |
| miRBase family | MIPF0000333 |
| Other data | |
| RNA type | microRNA |
| Domain | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-652 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, with expression levels of miRNAs and respective target mRNAs negatively correlated.
miR-652 expression is specific to cells of the myeloid lineage, in this instance to monocytes and granulocytes.[1]
miR-652 serum levels are significantly altered in alcoholic- or hepatitis-C-induced liver cirrhosis patients. They have been found to be down-regulated in the circulating monocytes of such patients, thus supporting the idea of an miR-652 role in the mediation of fibrogenic and inflammatory processes in the pathogenesis of liver cirrhosis.[2]
Circulating levels of miR-652 show gradual elevation with progression of liver cancer, as is also the case with miRNAs let-7a, let-7f, miR-34a, miR-98, miR-331 and miR-338.[3]
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