Natacha Rambova died of a heart attack at Las Encinas Hospital in Pasadena, California, at the age of 69. This marks the end of her life, which encompassed a diverse range of accomplishments in Hollywood and in the field of Egyptology. Her death concluded a life marked by creativity, controversy, and intellectual pursuits.

Natacha Rambova patented a doll she designed with a "combined coverlet". It was shortly after the beginning of her divorce proceedings from Rudolph Valentino. This event marks a step toward Natacha Rambova building her own solo career and starting a new independent professional path after her relationship with Valentino.