Usyk turned professional in 2013, starting his career in the cruiserweight division.

Usyk won his first title by defeating Daniel Bruwer via seventh-round technical knockout (TKO) for the interim WBO Inter-Continental cruiserweight title.

Usyk won his first world title in the cruiserweight division.

Usyk became the undisputed cruiserweight champion by winning the World Boxing Super Series cruiserweight tournament, defeating Murat Gassiev in the final and holding all four major world titles (WBA, WBC, IBF, and WBO).

Usyk vacated his cruiserweight titles to move up to the heavyweight division.

Usyk defeated Anthony Joshua to win the WBA, IBF, and WBO heavyweight titles.

Usyk defended his titles in a rematch against Anthony Joshua and won the vacant Ring magazine title.

Usyk defeated Tyson Fury to claim the WBC title and become the undisputed heavyweight champion.