Ōtemachi Station (大手町駅, Ōtemachi-eki) is a major subway station in Chiyoda, Tokyo, Japan, jointly operated by Tokyo Metro and Toei Subway. It is served by five lines, more than any other station on the Tokyo underground network, and is thus the biggest subway station in Tokyo. It is Tokyo Metro's second busiest station, after Ikebukuro.

Ōtemachi Station is within walking distance (either at street level or via underground passages) of Tokyo Station.

With the exception of the Mita Line, the station facilities of the remaining lines were inherited by Tokyo Metro after the privatization of the Teito Rapid Transit Authority (TRTA) in 2004.

35°41′05″N 139°45′57″E / 35.684699°N 139.765964°E / 35.684699; 139.765964