Allen established the Paul G. Allen Family Foundation to formalize and scale his philanthropic giving. The foundation focused on a wide range of causes, including science, technology, arts, and community development.

Allen launched the Allen Institute for Brain Science with a substantial financial commitment. The institute is dedicated to accelerating brain research and understanding the complexities of the human brain.

Allen established the Allen Institute for Cell Science to advance cell biology research. The institute aims to create a comprehensive understanding of cell behavior.

Allen founded the Allen Institute for Artificial Intelligence (AI2) to conduct research and development in artificial intelligence. AI2 focuses on solving fundamental problems in AI and creating AI technologies for the common good.

Allen supported numerous other philanthropic initiatives, including arts and culture organizations, educational programs, and disaster relief efforts. His total philanthropic giving amounted to billions of dollars.