Following his amateur hour win, Winchell began performing regularly on radio programs, further developing his comedic and ventriloquial act.

Winchell hosted his first national television program, "The Paul Winchell Show", on NBC. This was a pioneering children's program showcasing his ventriloquism with Jerry Mahoney.

His show moved to CBS, continuing its success and further establishing Winchell as a major television personality. This version emphasized comedy and musical numbers.

The show continued in syndication, expanding its reach and cementing Winchell's legacy in children's television. Different versions of the show continued to appear and reappear.

Winchell transitioned into a prolific voice acting career, providing voices for numerous animated characters, including Tigger in Disney's Winnie the Pooh franchise, Gargamel in The Smurfs, and many others. His voice work became a defining part of his later career.

A revamped version of his show aired in syndication, known as Winchell-Mahoney Time, continuing to entertain children with comedy sketches and educational segments.