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Proglucagon

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Proglucagon

Proglucagon is a protein that is a precursor of glucagon and several other components. It is cleaved from preproglucagon. Proglucagon is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon.

Preproglucagon in humans is encoded by the GCG gene and is composed of 180 amino-acid residues.


More specifically, preproglucagon is cleaved into the following components in different organs:

Proglucagon itself is a protein with three repeats of slightly different secretin family hormones to be cleaved to form mature hormones.

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protein precursor in Homo sapiens
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