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Princess Charlotte Sophie of Saxe-Coburg-Saalfeld, Duchess in Saxony (24 September 1731 – 2 August 1810) was a German duchess. She was the daughter of Franz Josias, Duke of Saxe-Coburg-Saalfeld and Princess Anna Sophie of Schwarzburg-Rudolstadt.
Charlotte Sophie married Louis, Hereditary Prince of Mecklenburg-Schwerin (6 August 1725 – 12 September 1778), younger son of Christian Ludwig II, Duke of Mecklenburg-Schwerin. They had two children:
| Name | Birth | Death | Marriage/notes |
|---|---|---|---|
| Friedrich Franz | 10 December 1756 | 1 February 1837 | Princess Louise of Saxe-Gotha-Altenburg m. 1 June 1775 at Gotha; had issue |
| Sophia Frederica | 24 August 1758 | 29 November 1794 | Hereditary Prince Frederick of Denmark and Norway m. 21 October 1774 at Copenhagen; had issue (including Christian VIII of Denmark) |
| Ancestors of Princess Charlotte Sophie of Saxe-Coburg-Saalfeld[1] |
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