Reno (/ˈriːnoʊ/ REE-noh) is a city in the northwest section of the U.S. state of Nevada, along the Nevada–California border. It is the county seat and most populous city of Washoe County. Sitting in the High Eastern Sierra foothills, in the Truckee River valley, on the eastern side of the Sierra Nevada, it is about 23 miles (37 km) northeast of Lake Tahoe. Known as "The Biggest Little City in the World", Reno is the 78th most populous city in the United States, the third most populous city in Nevada, and the most populous in Nevada outside the Las Vegas Valley. The city had a population of 264,165 at the 2020 census.

The city is named after Civil War Union major general Jesse L. Reno, who was killed in action during the American Civil War at the Battle of South Mountain, on Fox's Gap.

Reno is part of the Reno–Sparks metropolitan area, the second-most populous metropolitan area in Nevada after the Las Vegas Valley. Known as Greater Reno, it includes Washoe, Storey, and Lyon Counties; the independent city and state capital Carson City; and parts of Placer and Nevada Counties in California. The Reno metro area (along with the neighboring city Sparks) occupies a valley colloquially known as the Truckee Meadows.

For much of the twentieth century, Reno saw a significant number of people seeking to take advantage of Nevada's relatively lax divorce laws and the city gained a national reputation as a divorce mill. Today, Reno is a tourist destination known for its casino gambling and proximity to Lake Tahoe and the Sierra Nevada. The city is also home to the University of Nevada at Reno, the state's second-largest university by enrollment and the flagship campus of the University of Nevada system.

Archaeological finds place the eastern border of the prehistoric Martis people in the Reno area. As early as the mid-1850s, a few pioneers settled in the Truckee Meadows, a relatively fertile valley through which the Truckee River made its way from Lake Tahoe to Pyramid Lake. In addition to subsistence farming, these early residents could pick up business from travelers along the California Trail, which followed the Truckee westward, before branching off towards Donner Lake, where the formidable obstacle of the Sierra Nevada began.

Gold was discovered in the vicinity of Virginia City in 1850, and a modest mining community developed, but the discovery of silver in 1859 at the Comstock Lode led to a mining rush, and thousands of emigrants left their homes, bound for the West, hoping to find a fortune.

To provide the necessary connection between Virginia City and the California Trail, Charles W. Fuller built a log toll bridge across the Truckee River in 1859. A small community that served travelers soon grew near the bridge. After two years, Fuller sold the bridge to Myron C. Lake, who continued to develop the community by adding a grist mill, kiln, and livery stable to the hotel and eating house. He renamed it "Lake's Crossing". Most of what is present-day western Nevada was formed as the Nevada Territory from part of Utah Territory in 1861.

By January 1863, the Central Pacific Railroad (CPRR) had begun laying tracks east from Sacramento, California, eventually connecting with the Union Pacific Railroad at Promontory, Utah, to form the First transcontinental railroad. Lake deeded land to the CPRR in exchange for its promise to build a depot at Lake's Crossing. In 1864, Washoe County was consolidated with Roop County, and Lake's Crossing became the county's largest town. Lake had earned himself the title "founder of Reno". Once the railroad station was established, the town of Reno officially came into being on May 9, 1868. CPRR construction superintendent Charles Crocker named the community after Major General Jesse Lee Reno, a Union officer killed in the Civil War at the Battle of South Mountain.