Rhianna Pratchett wrote the script for Overlord, a darkly humorous action role-playing game where players control an evil Overlord. The game was well-received for its unique premise and witty writing.

She served as the Senior Writer on Mirror's Edge, a first-person action-adventure game known for its distinctive parkour gameplay and minimalist aesthetic. She was responsible for creating the story and characters.

Rhianna Pratchett was the lead writer for the Tomb Raider reboot, a critically acclaimed reimagining of the Lara Croft origin story. Her work focused on crafting a more vulnerable and relatable character for Lara, leading to critical acclaim.

Pratchett worked as the writer for the game Heavenly Sword, known for its narrative focus and cinematic presentation.

Rhianna Pratchett contributed to the writing of Rise of the Tomb Raider, the sequel to the 2013 reboot. She continued to develop Lara Croft's character and expand the game's narrative.