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Robert B. Corey
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Robert B. Corey (August 19, 1897 – April 23, 1971) was an American biochemist, mostly known for his role in discovery of the α-helix and the β-sheet with Linus Pauling.[1] Also working with Pauling was Herman Branson. Their discoveries were remarkably correct, with even the bond lengths being accurate until about 40 years later. The α-helix and β-sheet are two structures that are now known to form the backbones of many proteins.[2]
Key Information
Academic training
[edit]A childhood polio survivor, Corey received his undergraduate degree from the University of Pittsburgh, and his Ph.D. in chemistry from Cornell University.[3]
The findings of α-helix and β-sheet
[edit]At Caltech, the trio (Pauling, Corey and Branson) published a series of articles in the Proceedings of the National Academy of Sciences.[4][5][6][7][8]
The most revolutionary of the articles in PNAS is the one written on February 28, 1951.[8] That date was also Pauling's 50th birthday. It was called "The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain". In the paper, one odd thing is that the trio diagrammed the α-helix as a left-handed helix, although it is really a right-handed one. Another odd thing in the paper is that the 3(10) helix is almost never mentioned, although it is very common, while the γ-helix, which was another focus of the paper, is almost never found in nature.[9]
See also
[edit]References
[edit]- ^ "Structure of Proteins Found". The Buffalo News. 5 September 1951. p. 13.
- ^ "Artificial Making of Bone, Blood and Muscle is Forecast". L.A. Daily News. p. 8.
- ^ Simoni, Robert D. (1 November 2002). "Viral Proteins by X-ray Diffraction: Ralph Wyckoff and Robert Corey". The Journal of Biological Chemistry. 277 (44): 71–73. doi:10.1016/S0021-9258(19)72104-8 – via JSTOR.
- ^ Pauling, L., and R. B. Corey. 1950. Two hydrogen-bonded spiral configurations of the polypeptide chain. J. Am. Chem. Soc. 72:5349.
- ^ Pauling, L., and R. B. Corey. 1951. The structure of synthetic polypeptides. Proc. Natl. Acad. Sci. U.S.A. 37:241-50.
- ^ Pauling, L., and R. B. Corey. 1951. The pleated sheet, a new layer configuration of polypeptide chains. Proc. Natl. Acad. Sci. U.S.A. 37:2451-56.
- ^ Pauling, L., and R. B. Corey. 1953. A proposed structure for the nucleic acids. Proc. Natl. Acad. Sci. U.S.A. 39:84-97.
- ^ a b Pauling, L., R. B. Corey, and H. R. Branson. 1951. The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chains. Proc. Natl. Acad. Sci. U.S.A. 37:205-10.
- ^ "Prof. Corey's Research Has Great Value". The Republican. 5 September 1951. p. 7.
External links
[edit]- The Protein Papers by Christen Brownlee, in PNAS at 100: Classics of the Scientific Literature, special issue of the Proceedings of the National Academy of Sciences
- Robert Brainard Corey by Richard E. Marsh, Biographical Memoirs V.72 (1997) of the National Academy of Sciences
- Key Participants: Robert B. Corey – It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin, and Sickle Cell Anemia; and Key Participants: Robert B. Corey – Linus Pauling and the Race for DNA: A Documentary History
- National Academy of Sciences Biographical Memoir
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