Sam440, also known by Sam or its codename Samantha, is a line of modular motherboards produced by the Italian company ACube Systems Srl. The Sam440ep version is a motherboard based on the PowerPC 440EP system-on-a-chip processor which includes a double-precision FPU. It is made by AMCC. Their primary targets are the industrial and embedded markets, running operating systems such as Linux and AmigaOS 4.

At the time of AmigaOS 4.1 release in 2008, it was the only AmigaOS 4 compatible hardware available since the manufacturing of AmigaOne machines ceased in 2005; Sam440 was later succeeded by the Sam460ex (AmigaOne 500) and AmigaOne X1000.

Notable features of the Sam boards (including all versions):

Sam440ep was the first modular motherboard produced by ACube Systems Srl.

The specifications are the same as for the revisions before, except for:

There is no graphics chip on the Sam440ep-flex, so you have to use a PCI-graphics board.

The specifications are the same as for the flex prototype, except for:

On 2 April 2009, ACube announced the availability of SAM440ep-flex revision 2, it has the same specifications as the flex prototype except for: