Sam & Max Save the World is a graphic adventure video game developed by Telltale Games. The game was originally released as Sam & Max: Season One before being renamed in early 2009. Save the World was developed in an episodic fashion, comprising six episodes that were released for Microsoft Windows over the course of late 2006 and early 2007. The episodes were initially distributed online by GameTap and Telltale Games themselves, although the later retail releases of the game were published by The Adventure Company. A Wii port of the game was published in late 2008, and an Xbox Live Arcade version was released in mid-2009. A remaster of the game by Skunkape Games was released in December 2020 for Nintendo Switch and Microsoft Windows, in August 2021 for Xbox One, and in September 2022 for PlayStation 4.

Based on Steve Purcell's comic book series Sam & Max, the game follows the title characters Sam and Max—self-styled vigilante private investigators, the former an anthropomorphic dog and the latter a "hyperkinetic rabbity thing"—through several cases involving a hypnotism conspiracy. Each episode features one case with a contained story, with an underlying plot running through the series. The game was announced by Telltale Games in 2005 following the cancellation of Sam & Max: Freelance Police by LucasArts in the preceding year; many of the employees at Telltale Games were members of the Freelance Police development team.

The game received a positive response from critics, with praise bestowed on the game's humor, graphics and gameplay, but concerns were voiced over the low difficulty of the puzzles, repetition in design between episodes and the effectiveness of the story. Opinions dissented across the Atlantic; some British reviewers did not appreciate the writing in the way that American critics did. Nevertheless, the game has won several awards and is often cited by commentators as the first successful application of episodic distribution. The game was accompanied by a number of short machinima videos set between each episode. The game was followed by two episodic sequels: Sam & Max Beyond Time and Space in 2007 and Sam & Max: The Devil's Playhouse in 2010.

Sam & Max Save the World is a 3D graphic adventure game in which the player controls the character of Sam. The player has Sam explore the environments of the game and solve a series of puzzles using a simple point-and-click interface. The game's puzzles have logical solutions, although a number of them have far-fetched solutions due to the game's cartoon setting. Depending on the type of in-game entity a player selects using the cursor, the player can have Sam walk around an area, look at and comment on objects, pick up certain items or otherwise try to use them. Sam may also engage in conversation with non-player characters; when this occurs, the game presents a dialog tree with several subjects to pick from. Topics of conversation may directly involve the story or provide assistance with the game's puzzles, while others may be entirely unconnected. In some cases, the player may be able to choose dialog for Max to speak as well.

The game implements an inventory system to allow Sam to store any items that the player picks up during the course of the game. The player may select any of the items in the inventory and can then attempt to use them on objects in the game world or give them to other characters simply by clicking on the desired target. Unlike Save the World's predecessor, Sam & Max Hit the Road, inventory items are context specific, and cannot be used together or combined to create new items. Typically, Sam carries a gun that may be used to solve several puzzles.

The characters can travel between a variety of locations in the game using their black and white 1960 DeSoto Adventurer, which, when selected, will present the player with a list of available destinations. The DeSoto is also used for several driving sequences, usually involving pursuing or fleeing criminals in other vehicles. In these driving sequences, the player can use Sam's gun, the car's horn, or have Max attempt to communicate with other vehicles via a megaphone. In addition, special inventory items may be used to complete specific puzzles within these sequences. Driving sequences are also used for several minigames, such as pulling innocent drivers over for fabricated felonies. In keeping with the developer's heritage from the LucasArts adventure games, Sam & Max Save the World is designed so that the player characters cannot die or reach a complete dead-end.

Sam & Max Save the World is set in a universe that parodies American popular culture, and it follows the title characters of Sam and Max, the Freelance Police, a pair of vigilantes and private investigators. Sam is a level-headed but enthusiastic anthropomorphic dog who wears a blue suit and fedora. He is inquisitive, knowledgeable in obscure areas and tends to prefer the logical solution to problems, but he is not above using force. Max is described as a "hyperkinetic rabbity thing"; cunning, uninhibited and reveling in violence and mischief. His reactions to situations usually incorporate force but often with a seeming disregard for his own personal safety. Together, the Freelance Police operate out of a dilapidated office block in a dangerous New York City neighborhood, where they receive cases over the telephone from an unseen police commissioner.

There are several supporting characters that consistently appear throughout the episodes.