Samantha announced that she was diagnosed with dermatomyositis, an inflammatory disease. This marked a public disclosure of her health condition.

Samantha and Naga Chaitanya announced their separation and eventual divorce. This ended their marriage of nearly four years.

Samantha married actor Naga Chaitanya in Goa according to Christian customs, following their Hindu wedding the previous day. This marked the second wedding ceremony in their marriage celebrations.

Samantha married actor Naga Chaitanya in Goa according to traditional Hindu customs. This marked a significant personal event in her life.

The release date of 'Ye Maaya Chesave,' Samantha's debut Telugu film. This film marked the beginning of her acting career and was a critical and commercial success, earning her the Filmfare Award for Best Female Debut – South.

Samantha Ruth Prabhu was born in Madras (now Chennai), Tamil Nadu, India. This marks the beginning of her life and career as a prominent actress in the Telugu and Tamil film industries.