Upon moving to Bikini Bottom, Sandy constructs the Treedome to create a terrestrial environment, allowing her to live and conduct research underwater. This is her first major invention demonstrated in the show.

Throughout the series, Sandy demonstrates numerous inventions, ranging from teleportation devices to shrinking machines, showcasing her constant pursuit of scientific discovery and her boundless creativity. She also experiments regularly, often with SpongeBob as a willing (or unwilling) subject.

Episodes like 'Pressure' hint at Sandy's interest in space travel and exploration, as she tries to demonstrate the superiority of land creatures to her underwater friends, including a rocket flight to the moon. While perhaps not successful in its stated goal, it points to her ongoing research.

Sandy often uses her scientific knowledge to solve problems faced by herself and her friends, from fixing broken machinery to understanding ecological issues within Bikini Bottom. Her expertise is a valuable resource for the community.