Santo contra los Zombies (also known as Santo vs. the Zombies) is a 1961 Mexican superhero film directed by Benito Alazraki. It depicts the popular character El Santo in a pulp-style film.

After the police are unable to stop a crime wave by zombies, they turn to Santo for help.

This was one of the earliest Santo films and the first to be distributed in the US.

Writing in The Zombie Movie Encyclopedia, academic Peter Dendle said, "The adventure movie with its comic-book plot, hero, and villain is fun to watch in an MST-3K spirit".