The Security and Prosperity Partnership of North America (SPP) was a supra-national level dialogue with the stated purpose of providing greater cooperation on security and economic issues. The Partnership was founded in Waco, Texas, on March 23, 2005, by Prime Minister of Canada Paul Martin, President of Mexico Vicente Fox, and U.S. President George W. Bush. It was the second of such regional-level initiatives involving the United States following the 1997 Partnership for Prosperity and Security in the Caribbean (PPS).

Since August 2009, the SPP is no longer active. It has been largely superseded by the annual North American Leaders' Summit, an event that was established as part of the SPP.

The SPP was neither a treaty nor a trade agreement.

The initial SPP Working Groups were the Manufactured Goods and Sectoral and Regional Competitiveness Working Group, E-Commerce & ICT Working Group, Energy Working Group, Transportation Working Group, Food & Agriculture Working Group, Environment Working Group, Financial Services Working Group, Business Facilitation Working Group, Movement of Goods Working Group, and Health Working Group. The Transportation Working Group was formed to analyze border trade and traffic flows. The U.S. Health and Human Services Office of the Assistant Secretary for Preparedness and Response (ASPR) led the SPP Health Working Group, in order to improve the ability of three countries to mutually assist each other during public health emergencies, to exchange information for policy planning, and to improve product safety.

The stated goals of the SPP were cooperation and information sharing, improving productivity, reducing the costs of trade, enhancing the joint stewardship of the environment, facilitating agricultural trade while creating a safer and more reliable food supply, and protecting people from disease.

On 26 February 2008, Canada's Minister of Finance Jim Flaherty, announced his government's 2008 budget, which included "$29 million over two years to meet priorities under the Security and Prosperity Partnership of North America".

As part of SPP, an annual trilateral summit was held between the leaders of the three countries. Following the cancellation of the SPP in 2009, meetings continued as the North American Leaders' Summit.

The North American Competitiveness Council (NACC) was an official tri-national working group of the SPP. It was created at the second summit of the SPP in Cancún, Quintana Roo, Mexico, in March 2006. The SPP is an agreement between the leaders of the United States, Canada and Mexico to work towards a more integrated North American economy and security region. Composed of 30 corporate representatives from some of North America's largest companies, the North American Competitiveness Council has been mandated to set priorities for the SPP and to act as a stable driver of the integration process through changes in government in all three countries.