Shinji Mikami joins Capcom, initially as a planner. His early roles likely involved contributing to various projects, gaining experience with the company's development processes.

Mikami works as a planner on the SNES adaptation of Who Framed Roger Rabbit, gaining early experience in game development. He is uncredited.

He works as a planner on Goof Troop for the SNES, gaining further experience.

Mikami directs the original Resident Evil for the PlayStation. This groundbreaking title popularizes the survival horror genre, featuring pre-rendered backgrounds, fixed camera angles, and a focus on resource management and atmosphere. It becomes a massive critical and commercial success.

Mikami serves as the producer for Resident Evil 2, ensuring the sequel expands upon the original's success with improved graphics, a more elaborate story, and the innovative Zapping System. The game is a critical and commercial hit.

Mikami directs Resident Evil 3: Nemesis, which introduces the iconic Nemesis creature and a more action-oriented gameplay style compared to its predecessors. Although commercially successful, some fans felt it deviated slightly from the series' survival horror roots.

Mikami directs Dino Crisis, another survival horror title, this time focusing on dinosaurs instead of zombies. It showcases Mikami's ability to create suspenseful and engaging gameplay within different settings.

Mikami directs the original Devil May Cry. Originally conceived as a Resident Evil sequel, it evolved into a distinct action-adventure title, known for its stylish combat and challenging gameplay. He's credited with changing the development direction when it became too action focused to remain Resident Evil.

Mikami oversees the development of the Resident Evil remake for the GameCube. This reimagining of the original game features vastly improved graphics, enhanced environments, and new gameplay elements, solidifying its status as a classic.

Mikami directs Resident Evil 4, a significant departure from the series' established formula. The game introduces an over-the-shoulder camera perspective, more action-oriented gameplay, and a focus on set pieces and combat. It is widely regarded as one of the greatest video games of all time, but its changes sparked debate among long-time fans.

Mikami leaves Capcom after completing work on Resident Evil 4. His departure is influenced by creative differences and a desire to pursue new opportunities.