Shiselweni is a region of Eswatini, located in the south of the country. It has an area of 3,786.71 km² and a population of 204,111 (2017). Its administrative center is Nhlangano. It borders Lubombo in the northeast and Manzini Region in the northwest.

Shiselweni is subdivided into 14 tinkhundla (or constituencies). These are local administration centres, and also parliamentary constituencies. Each inkhundla is headed by an indvuna yenkhundla or governor with the help of bucopho. The tinkhundla are further divided into imiphakatsi (or chiefdoms). The present tinkhundla are:

Christianity and Islam are the main religions in the region.

27°00′S 31°40′E / 27.000°S 31.667°E / -27.000; 31.667