V. A. Shiva Ayyadurai was born in Bombay (now Mumbai), India, to Tamil Indian parents. His early life was steeped in Indian culture before his family immigrated to the United States, setting the stage for his later scientific pursuits and entrepreneurial endeavors in a vastly different cultural and technological landscape.

Ayyadurai's family emigrated to the United States. This move was transformative, exposing him to advanced technological opportunities that would be formative for his later academic and professional life. The exposure to American innovation fueled his interest in computer science and programming.

As a 14-year-old student at Livingston High School in New Jersey, Ayyadurai began working at the University of Medicine and Dentistry of New Jersey (UMDNJ). During this time, he created a software program he called "EMAIL," designed to replicate the interoffice mail system electronically. He copyrighted the name "EMAIL" in 1982. This is the period where the core of his later claim to have invented email stems from, although his program was not the first electronic mail system.

Ayyadurai obtained a U.S. copyright for the computer program "EMAIL." This copyright has been central to his claims of inventing email, although it's important to note that copyright protects the specific expression of an idea (the code) rather than the underlying concept. His claim has been challenged due to the existence of earlier electronic mail systems, such as ARPANET mail, which predated his program.

Ayyadurai pursued higher education at the Massachusetts Institute of Technology (MIT), earning four degrees including a Ph.D. in biological engineering. His academic work at MIT focused on systems biology and highlighted his interdisciplinary approach to scientific inquiry. These degrees lent him credibility in scientific circles, though his claims about email continued to generate controversy.

Ayyadurai founded several companies, including Millennium Cyberworks and EchoMail. EchoMail focused on email management and filtering technologies. These ventures aimed to capitalize on innovations in email processing, even as debate about Ayyadurai's contributions to the fundamental invention of email continued.

Ayyadurai became embroiled in several high-profile lawsuits and public disputes, particularly related to his claims about inventing email. These legal battles involved Gawker Media and Techdirt, among others. The disputes highlighted the complex intersection of intellectual property, journalism, and the internet age.

Ayyadurai launched a campaign for U.S. Senate in Massachusetts as an independent candidate. His political platform focused on issues such as education and innovation. While his campaign did not result in electoral victory, it significantly raised his public profile and allowed him to disseminate his views on a wider stage.

Ayyadurai ran for U.S. Senate again, this time as a Republican in the Massachusetts primary. Although he lost the primary, the run represented his continued involvement in political activism and offered a platform for his views.

Ayyadurai continues to be active as an entrepreneur, public speaker, and advocate for his views on science, technology, and politics. He remains a controversial figure, with ongoing debates about his claims of inventing email and the broader impact of his work.