Sofia is a region in northern Madagascar. It is named for the Sofia River. It is the second largest Malagasy region (behind Atsimo-Andrefana) with an area of 50,100 km² (19,300 sq mi), and had a population of 1,500,227 in 2018. Antsohihy is the administrative capital.

Sofia Region is divided into seven districts, which are sub-divided into 108 communes.

Sofia is crossed by the National Road 4 (Antananarivo-Mahajanga), National Road 6 (Antsohihy-Diego Suarez), the National road 31 (Antsohihy to Mandritsara) and National road 32 (Antsohihy to Bealanana).

Sofia disposes of the highest concentration of mangroves in Madagascar with a total surface of 450 km2.

14°52′47″S 47°59′15″E / 14.87961°S 47.987518°E / -14.87961; 47.987518