Statesboro is the most populous city in and the county seat of Bulloch County, Georgia, United States. Located in the southeastern part of the state, its population was 33,438 at the 2020 census. It is the principal city of the Statesboro micropolitan area, which had 81,099 residents, and is part of the Savannah–Hinesville–Statesboro combined statistical area.

The city was chartered in 1803, starting as a small trading community providing basic essentials for surrounding cotton plantations. This drove the economy throughout the 19th century, both before and after the American Civil War. In 1906, Statesboro was selected as the home of the First District A&M School, a land grant college that eventually developed into Georgia Southern University.

Statesboro inspired the blues song "Statesboro Blues", written by Blind Willie McTell in the 1920s, and covered in a well-known version by the Allman Brothers Band. In 2017, Statesboro was selected in the top three of the national America's Best Communities competition and was named one of nine Georgia "live, work, play" cities by the Georgia Municipal Association.

In 1801, George Sibbald of Augusta donated a 9,301-acre (37.64 km²) tract for a centrally located county seat for the growing agricultural community of Bulloch County. The area was developed by white planters largely for cotton plantations that were worked by black slave labor. In December 1803, the Georgia legislature created the town of Statesborough. The community most likely was named after the notion of states' rights, an issue central in the 1800 United States presidential election. In 1866 the state legislature granted a permanent charter to the city, changing the spelling of its name to the present "Statesboro."

During the Civil War and General William T. Sherman's famous March to the Sea through Georgia, a Union officer asked a saloon proprietor for directions to Statesboro. The proprietor replied, "You are standing in the middle of town," indicating its small size. The soldiers destroyed the courthouse, a log structure that doubled as a barn when court was not in session. After the Civil War, the small town began to grow, and Statesboro has developed as a major town in southeastern Georgia. Many freedmen stayed in the area, working on plantations as sharecroppers and tenant farmers.

Following the Reconstruction era, racial violence of whites against blacks increased. In the era from 1880 to 1930, Georgia had the highest rate of lynchings of any state in the nation. Among them were three black men who were lynched and burned to death on August 16, 1904, near Statesboro. A fourth man was lynched later in the month in Bulloch County. After a white farm family was killed, the white community spread unfounded rumors of black clergy urging blacks to violence against whites, and more than twelve black men were arrested in this case.

Paul Reed and Will Cato were convicted of the Hodge family murders by an all-white jury and sentenced to death on August 16, 1904, but they were abducted that day from the courthouse by a lynch mob and brutally burned to death. Handy Bell, another suspect, was lynched and burned by a mob that night. White violence against blacks did not end; both men and women were physically attacked on the streets. Two more black men were lynched in August 1904: Sebastian McBride in Portal, another town in Bulloch County, and A.L. Scott in Wilcox County.

To escape oppression and violence, many African Americans left Statesboro and Bulloch County altogether, causing local businessmen to worry about labor shortages in the cotton and turpentine industries. African Americans made a Great Migration from the rural South to northern cities in the first half of the 20th century. Local effects can be seen in the drop in Statesboro population growth from 1910 to 1930 on the census tables below in the "Demographics" section.