Street Smarts is an American game show that featured two in-studio contestants trying to predict the outcome of interviews of people who were found on the street. The show, which was hosted by Frank Nicotero, aired in syndication from 2000 to 2005. Nicotero would be on locale (via archived footage) with the on the street contestants, virtually any and everywhere in the United States. The in studio gameplay however, was at G4 and TMZ, headquarters, Victory Studios, in Glendale, California.

The show features two in-studio contestants competing against each other; and three voluntary "on the street" contestants/participants, (who were approached to be on the program in an unsuspecting manner, and who were also generally referred to as "savants" by Nicotero), who are civilians, situated in a popular outdoor metropolis area, in which the "savants" are featured via archived, prior pre-recorded vox populi interviews moderated by Nicotero. The "savants" are presented through large projection screens in the studio (and the archival footage of them will be shown in studio, and to the home audience, throughout the program).

The "savants" were usually almost always, at a populous party event, festival, happening, social gathering, or function, (some "savants" also were on vacation, on holiday, or were out-of-towners, or tourists). This aspect was probably done to take the "savants" out of their element, making incorrect responses likely to happen based on the current situation. Nicotero would also constantly soft talk, sweet talk, flatter himself, use sarcasm, and tease with the "savants", making the trivia questions he asked, come across off guard to the "savants", leading the "savants", to possibly misunderstand what Nicotero intentionally meant, and also possible unpredictable comedic responses.

The in-studio contestants are revealed to the audience. The three "savants" are also revealed, and they describe themselves to the audience (through archival footage shown in-studio, and to the home audience.)

Realistically based only on impressions given by the "savants" to the in-studio contestants, the in-studio contestants must predict whether the "savants" gave a correct or incorrect answer, based on general knowledge and pop culture questions, exclaimed by Nicotero to the "savants."

Occasionally, the "savants", were given a sign, with a picture of a celebrity on it, and asked to name whom this person was, also the "savants" were given a large sign with the name of a word, in which the "savant" was asked to pronounce the word, or explain the definition of the word. The "savants", may also be asked to make gestures, or signals, in response to a question as well.

A question is posed, and the studio contestants must predict which of the three "savants" gave the correct answer. A correct prediction earns $100. Three questions are asked in this round, and sometimes two "savants" will have answered a question correctly. Sometimes, as an aside, Nicotero will call for a wrong-answer clip to be played, to add humor to the show.

In-studio contestants are allowed to pick the same "savant", if they wish.