Neil Gehrels Swift Observatory, previously called the Swift Gamma-Ray Burst Explorer, is a NASA three-telescope space observatory for studying gamma-ray bursts (GRBs) and monitoring the afterglow in X-ray, and UV/visible light at the location of a burst. It was launched on 20 November 2004, aboard a Delta II launch vehicle. Headed by principal investigator Neil Gehrels until his death in February 2017, the mission was developed in a joint partnership between Goddard Space Flight Center (GSFC) and an international consortium from the United States, United Kingdom, and Italy. The mission is operated by Pennsylvania State University as part of NASA's Medium Explorer program (MIDEX).

The burst detection rate is 100 per year, with a sensitivity ~3 times fainter than the BATSE detector aboard the Compton Gamma Ray Observatory. The Swift mission was launched with a nominal on-orbit lifetime of two years. Swift is a NASA MIDEX (medium-class Explorer) mission. It was the third to be launched, following IMAGE and WMAP.

While originally designed for the study of gamma-ray bursts, Swift now functions as a general-purpose multi-wavelength observatory, particularly for the rapid follow-up and characterization of astrophysical transients of all types. As of 2020, Swift received 5.5 Target of Opportunity observing proposals per day, and observes ~70 targets per day, on average.

Swift is a multi-wavelength space observatory dedicated to the study of gamma-ray bursts. Its three instruments work together to observe GRBs and their afterglows in the gamma-ray, X-ray, ultraviolet, and optical wavebands.

Based on continuous scans of the area of the sky with one of the instrument's monitors, Swift uses momentum wheels to autonomously slew into the direction of possible GRBs. The name "Swift" is not a mission-related acronym, but rather a reference to the instrument's rapid slew capability, and the nimble swift (bird of the same name). All of Swift's discoveries are transmitted to the ground and those data are available to other observatories which join Swift in observing the GRBs.

In the time between GRB events, Swift is available for other scientific investigations, and scientists from universities and other organizations can submit proposals for observations.

The Swift Mission Operation Center (MOC), where commanding of the satellite is performed, is located in State College, Pennsylvania and operated by the Pennsylvania State University and industry subcontractors. The Swift main ground station is located at the Broglio Space Center near Malindi on the coast of eastern Kenya, and is operated by the Italian Space Agency (ASI). The Swift Science Data Center (SDC) and archive are located at the Goddard Space Flight Center outside Washington, D.C. The United Kingdom Swift Science Data Centre is located at the University of Leicester.

The Swift satellite bus was built by Spectrum Astro, which was later acquired by General Dynamics Advanced Information Systems, which was in turn acquired by Orbital Sciences Corporation (now Northrop Grumman Innovation Systems).