Witchblade is an American comic book series published by Top Cow Productions, an imprint of Image Comics, which ran from November 1995 to October 2015. The series was created by Top Cow founder and owner Marc Silvestri, editor David Wohl, writers Brian Haberlin and Christina Z, and artist Michael Turner.

The Witchblade comic was adapted into a television series in 2001, as well as an anime, a manga and a novel in 2006. A feature film based on the comic, titled The Witchblade, was announced for a 2009 release, but was never produced. A second Witchblade television series was announced for development in January 2017, but no further updates have been reported.

Top Cow relaunched Witchblade comic in December 2017 with the creative team of writer Caitlin Kittredge and artist Roberta Ingranata. The series features journalist Alex Underwood as the main character.

The first of a new Witchblade comic series was released in July 2024 featuring a new Witchblade creative team: writer Marguerite Bennett, artist Giuseppe Cafaro, colorist Arif Prianto and letterer Troy Peteri.

The series follows Sara Pezzini, an NYPD homicide detective who comes into possession of the Witchblade, a supernatural, sentient gauntlet that bonds with a female host and provides her with a variety of powers in order to fight supernatural evil.^{[citation needed]} Sara struggles to hone the powers of the Witchblade and fend off those with a nefarious interest in it, such as entrepreneur Kenneth Irons and his bodyguard Ian Nottingham.^{[citation needed]}

The Witchblade is a sentient gauntlet; described as being the offspring of the Darkness and Angelus and serving as the balance between the two forces. Often described as being a male entity, though occasionally taking a feminine form whenever it manifests itself, the Witchblade symbiotically bonds itself to humans—typically women—to serve as its bearers.

A New York City detective, Sara first encountered the Witchblade while on a case with her then partner, Michael Yee. After both officers were mortally wounded by criminal Ian Nottingham, the gauntlet suddenly left the possession of his employer, Kenneth Irons, and gave its power to Sara, healing her wounds. When Jackie Estacado, the host of the Darkness, was possessed by its influence, he impregnated a temporarily comatose Sara as part of an effort to sway the Witchblade's balance. However, neither of them became aware of this until later. Eventually, Sara met and relinquished the Witchblade to Danielle Baptiste, to whom the artifact had a strong affinity. Amidst complications during the birth of her daughter, Hope, Sara's life was saved when she received half of the Witchblade from Dani. Sara now possesses the full Witchblade and Dani is now the host for the Angelus.

Danielle is a young ballet dancer who was born in New Orleans. After moving to New York to pursue her career, she experienced a mysterious dream in which she saw herself inheriting great power by means of a mystical gauntlet. Dani found herself taking a walk and wandering to an antique shop the next day. It was there that she encountered Sara Pezzini, the current host of the Witchblade. Having become pregnant, Sara realized that the time had come for her to relinquish the artifact. Sara relinquished the Witchblade to Dani when she realized that she was meant to become its next host. While exploring her powers, Dani faced and overcame a number of mystical opponents. Eventually, Dani returned half of the Witchblade to Sara in order to save Sara's life following the birth of her child. She currently does not have any portion of the Witchblade as she is the present host to the Angelus.