In common usage, technoscience refers to the entire long-standing and global human activity of technology, combined with the relatively recent scientific method that occurred primarily in Europe during the 17th and 18th centuries. Technoscience is the study of how humans interact with technology using the scientific method. Technoscience thus comprises the history of human application of technology and modern scientific methods, ranging from the early development of basic technologies for hunting, agriculture, or husbandry (e.g. the well, the bow, the plow, the harness) and all the way through atomic applications, biotechnology, robotics, and computer sciences. This more common and comprehensive usage of the term technoscience can be found in general textbooks and lectures concerning the history of science.

The relationship with the history of science is important in this subject and also underestimated, for example, by more modern sociologists of science. Instead, it is worth emphasizing the links that exist between books on the history of science and technology and the study of the relationship between science and technology within a framework of social developments. The generational leap between historical periods and scientific discoveries, the construction of machines, and the creation of tools in relation to the technological changes that occurs in very specific situations is important to consider.

An alternate, more narrow usage occurs in some philosophical science and technology studies. In this usage, technoscience refers specifically to the technological and social context of science. Technoscience recognises that scientific knowledge is not only socially coded and historically situated but sustained and made durable by material (non-human) networks. Technoscience states that the fields of science and technology are linked and grow together, and scientific knowledge requires an infrastructure of technology in order to remain stationary or move forward.

The latter, philosophic use of the term technoscience was popularized by French philosopher Gaston Bachelard in 1953. It was popularized in the French-speaking world by Belgian philosopher Gilbert Hottois in the late 1970s and early 1980s, and entered English academic usage in 1987 with Bruno Latour's book Science in Action.

In translating the concept to English, Latour also combined several arguments about technoscience that had circulated separately within science and technology studies (STS) before into a comprehensive framework:

The concept of technoscience is considered in three levels: a descriptive-analytic level, a deconstructivist level, and a visionary level.

On a descriptive-analytic level, technoscientific studies examine the decisive role of science and technology in how knowledge is being developed. What is the role played by large research labs in which experiments on organisms are undertaken, when it comes to a certain way of looking at the things surrounding us? To what extent do such investigations, experiments and insights shape views of 'nature' and of human bodies? How do these insights link to the concept of living organisms as biofacts? To what extent do such insights inform technological innovation? Can the laboratory be understood as a metaphor for social structures in their entirety?

On a deconstructive level, theoretical work is being undertaken on technoscience to address scientific practices critically, e.g. by Bruno Latour (sociology), by Donna Haraway (history of science), and by Karen Barad (theoretical physics). It is pointed out^{[by whom?]} that scientific descriptions may be only allegedly objective; that descriptions are of a performative character, and that there are ways to de-mystify them. Likewise, new forms of representing those involved in research are being sought.