In rocketry, range safety or flight safety is ensured by monitoring the flight paths of missiles and launch vehicles, and enforcing strict guidelines for rocket construction and ground-based operations. Various measures are implemented to protect nearby people, buildings and infrastructure from the dangers of a rocket launch.

Governments maintain many regulations on launch vehicles and associated ground systems, prescribing the procedures that need to be followed by any entity aiming to launch into space. Areas in which one or more spaceports are operated, or ranges, issue closely guarded exclusion zones for air and sea traffic prior to launch, and close off certain areas to the public.

Contingency procedures are performed if a vehicle malfunctions or veers off course mid-flight. Sometimes, a range safety officer (RSO) commands the flight or mission to end by sending a signal to the flight termination system (FTS) aboard the rocket. This takes measures to eliminate any means with which the vehicle could endanger anyone or anything on the ground, most often through the use of explosives. Flight termination could also be triggered autonomously by a separate computer unit on the rocket itself.

Before each launch, the area surrounding the launch pad is evacuated, and notices to aviators and boatsmen to avoid certain locations on launch day are given. This facilitates the creation of a designated area for rockets to launch, called the launch corridor. The borders of the launch corridor are called the destruct lines. The exact coordinates of the launch corridor are dependent on weather and wind directions, and the properties of the launch vehicle and its payload. Launches can be postponed or scrubbed because of a boat, ship or aircraft entering the launch corridor.

To assist the range safety officer (RSO) in monitoring the launch and making eventual decisions, there are many indicators showing the condition of the space vehicle in flight. These included booster chamber pressures, vertical plane charts (later supplanted by computer-generated destruct lines), and height and speed indicators. Supporting the RSO for this information were a supporting team of RSOs reporting from profile and horizontal parallel wires used at liftoff (before radar technology was available) and telemetry indicators. Throughout the flight, RSOs pay close attention to the instantaneous impact point (IIP) of the launch vehicle, which is constantly updated along with its position; when a rocket is predicted to cross one of the destruct lines in flight because of any reason, a destruct command is issued to prevent the vehicle from endangering people and assets outside of the safety zone. This involves sending coded messages (typically sequences of audio tones, kept secret before launch) to special redundant UHF receivers in the various stages or components of the launch vehicle. Previously, the RSO transmitted an 'arm' command just before flight termination, which rendered the FTS usable and shut down the engines of liquid-fueled rockets. Now, the FTS is usually armed just before launch. A separate 'fire' command detonates explosives, typically linear shaped charges, to disable the rocket.

Reliability is a high priority in range safety systems, with extensive emphasis on redundancy and pre-launch testing. Range safety transmitters operate continuously at very high power levels to ensure a substantial link margin. The signal levels seen by the range safety receivers are checked before launch and monitored throughout flight to ensure adequate margins. When the launch vehicle is no longer a threat, the range safety system is typically safed (shut down) to prevent inadvertent activation. The S-IVB stage of the Saturn 1B and Saturn V rockets did this with a command to the range safety system to remove its own power.

In the US space program, range safety is usually the responsibility of a Range Safety Officer (RSO), affiliated with either the civilian space program led by NASA or the military space program led by the Department of Defense, through its subordinate unit the United States Space Force. At NASA, the goal is for the general public to be as safe during range operations as they are in their normal day-to-day activities. All US launch vehicles are required to be equipped with a flight termination system.

Range safety has been practiced since the early launch attempts conducted from Cape Canaveral in 1950. Space vehicles for sub-orbital and orbital flights from the Eastern and Western Test Ranges were destroyed if they endangered populated areas by crossing pre-determined destruct lines encompassing the safe flight launch corridor.^{[citation needed]} After initial lift-off, flight information is captured with X- and C-band radars, and S-Band telemetry receivers from vehicle-borne transmitters.^{[citation needed]} At the Eastern Test Range, S and C-Band antennas were located in the Bahamas and as far as the island of Antigua, after which the space vehicle finished its propulsion stages or is in orbit.^{[citation needed]} Two switches were used, arm and destruct. The arm switch shut down propulsion for liquid propelled vehicles, and the destruct ignited the primacord surrounding the fuel tanks.^{[citation needed]}