The Tōhoku Main Line (Japanese: 東北本線, Hepburn: Tōhoku-honsen) is a 575.7-kilometre-long (357.7 mi) railway line in Japan operated by the East Japan Railway Company (JR East). The line runs from Ueno Station in Ueno, Tokyo through major cities including Saitama, Utsunomiya, Fukushima, and Sendai, terminating at Morioka in Iwate Prefecture. The line originally extended to Aomori, but was truncated following the extension of the Tōhoku Shinkansen beyond Morioka, which largely parallels the former route.

A portion of the Tōhoku Main Line is shared with the Keihin–Tōhoku Line (between Ueno and Ōmiya Station in Ōmiya-ku, Saitama) and the Saikyō Line (between Akabane Station in the Kita ward of Tokyo and Ōmiya Station).

In regular service, JR East applies different service names to sections of the Tōhoku Main Line. The 163.5-kilometre-long (101.6 mi) section between Tokyo Station and Kuroiso Station in Nasushiobara, Tochigi Prefecture is referred to as the Utsunomiya Line, while the remaining northern portion is referred to as the Tōhoku Line. This distinction reflects a change in electrification from 1,500 V DC south of Kuroiso to 20 kV 50 Hz AC north of the station; as a result, there are no regularly scheduled passenger services operating through Kuroiso Station.

These lists are separated by service patterns provided on the Tōhoku Main Line.

The section between Tokyo and Kuroiso is known as the Utsunomiya Line.

All stations are located in Fukushima Prefecture.

Legends:

All stations are located in Iwate Prefecture.