The Truss ministry began on 6 September 2022 when Liz Truss was invited by Queen Elizabeth II—two days before the monarch's death—to succeed Boris Johnson as prime minister of the United Kingdom. Johnson had resigned as leader of the Conservative Party the previous day after Truss was elected as his successor. The Truss ministry was formed from the 2019 Parliament of the United Kingdom, as a Conservative majority government.

On 20 October 2022, amid growing disapproval of her leadership from within the Conservative Party, Truss announced her resignation, making her tenure the shortest in the history of the United Kingdom. She resigned as Conservative Party leader on 24 October and as prime minister on 25 October. The cabinet was dissolved following the appointment of Rishi Sunak as prime minister on 25 October.

There were resignations from the Truss ministry after forming a government on 6 September 2022. Truss faced the departure of two cabinet ministers and one junior minister. In addition, she dismissed ministers that served under the previous government.