UFC Fight Night: Barboza vs. Murphy (also known as UFC Fight Night 241, UFC on ESPN+ 99 and UFC Vegas 92) was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on May 18, 2024, at the UFC Apex facility, in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States.

A featherweight bout between Edson Barboza and Lerone Murphy headlined the event.

A women's bantamweight bout between Hailey Cowan and Tamires Vidal was expected to take place at the event. They were originally scheduled to meet at UFC on ESPN: Vera vs. Sandhagen in March 2023, but Vidal pulled out due to undisclosed medical reasons. In turn, Cowan was pulled from the event due to a broken leg and replaced by Melissa Gatto.

Former UFC Flyweight Championship challenger (also The Ultimate Fighter: Tournament of Champions flyweight winner) Tim Elliott and Tatsuro Taira was expected to take place at the event. However, Elliott withdrew due to an undisclosed injury and Taira was rescheduled against Joshua Van at UFC 302.

A light heavyweight bout between Oumar Sy and Rodolfo Bellato was scheduled for this event. However, Bellato withdrew for unknown reasons and was replaced by Antonio Trócoli. In turn, Trócoli was replaced by promotional newcomer Tuco Tokkos for undisclosed reasons.

The following fighters received $50,000 bonuses.